At Artax Biopharma our objective is to develop therapies that allow lasting and specific responses against T-cell mediated inflammatory and autoimmune diseases. Our science focuses on the interaction between T-cell Receptors (TCR) and Nck, a cytoplasmic adapter protein that plays a role in T-cell activation.
Mechanism of action
Once TCR is activated, it undergoes a conformational change that results in the recruitment of different proteins, including Nck, constituting the “TCR signalosome,” which is responsible for signal transduction and cell activation. As a result, the TCR conformational change is stabilized and TCR activation is efficiently transmitted. Scientific evidence points to Nck recruitment as a fundamental early step in TCR signaling, representing a target to modulate the immune response selectively.